Upregulation of FOXP3+ Regulatory T Lymphocytes and CD8+ Lymphocytes in Patients with High-Grade Squamous Intraepithelial Lesions Correlated with HPV Infection

Abstract Modern therapeutic strategies for precancerous cervical intraepithelial neoplasia (CIN) focus on immune-modulatory and cancer vaccination. The local immune status in CIN could influence HPV infection persistence, progression carcinogenesis. We analysed the role of FOXP3+ regulatory T lymphocytes, CD4+ CD8+ lymphocytes I, II III patients with without infection. Sixty-two were enrolled study. Each patient underwent a colposcopy-guided biopsy. CD4+,CD8+ detected by immunostaining tissue samples obtained from control group (n = 10), I 20), 14) 18) lesions. was assayed Aptima. results showed that numbers did not differ between II, III. However, had significantly upregulated CD8+T compared to I. In addition, increased FOXP3 + which associated status. Upregulation CD8-positive suggested pivotal counteracting host response